miRNA in Toxicogenomics Poster ? Presented at Society of ...

What are miRNAs? functions in toxicogenomics?

1.miRNAs are effectors of environmental influences on gene expression. Thus miRNAs play an important role in the cellular response to toxicants and disease.

2.The expression of miRNAs, like many of the genes important in toxicology, can be regulated by xenobiotics and DNA methylation.

3.Xenobiotic-mediated miRNA expression has been directly linked with downstream protein expression and cell proliferation.

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Application of Systems Biology Approach ? Because miRNAs cause translational repression of target effector proteins, their overexpression or underexpression can precipitate a biological effect depending on the role of the target effector protein in a biological pathway.

1.The involvement of miRNA deregulation in the early stages of lung, liver and breast carcinogenesis induced by chemical carcinogens, suggesting their major role as contributors to the pathogenesis of cancer.

2.Environmental exposures, particularly in early development can induce epigenetic changes, which may be transmitted in subsequent generations or serve as basis of diseases developed later in life.

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Biomarkers for Exposure Assessment ? miRNA profiling in response to toxic compounds can provide toxicant-specific profiles

1.miRNA expression profiles distinguish the carcinogenic effects of chemical toxins in specific organs.

2.miRNAs expression can be used as biomarkers of chemical exposure in risk assessment of chemical carcinogenesis

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Molecular Basis for Susceptibility & Resistance ? miRNAs play a fundamental role in toxicological phenomenon such as cellular responses to xenobiotic stress, susceptibility and resistance.

1.miRNAs can suppress resistance to anticancer cytotoxic therapy

2.Differences in the susceptibility to carcinogenesis may be determined by the variations in miRNA expression response to toxins.

3.miRNA expression profiling can be used to identify genetic susceptibility to pollutants.

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Therapeutic Potential of miRNA ? Identification of miRNAs that play essential roles in disease to act as drugs or possible therapeutic targets.

1.Drug combinations can sensitize cancer cells via miRNA pathways.

2.Restoring miRNA expression is a novel therapeutic approach to sensitizing and suppressing the growth of resistant tumors.

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Source: http://www.lcsciences.com/news/mirna-in-toxicogenomics-poster-presented-at-society-of-toxicology-meeting

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